Under the direction of Adam Konopka, PhD, MS, the Musculoskeltal Aging & Metabolism Laboratory (MAML) uses a translational research approach to understand the mechanisms involved in the onset and treatment of aging and age-related diseases.
The MAML lab’s current research has two main themes: age-related loss of skeletal muscle health and osteoarthritis. The lab is currently investigating how skeletal muscle mitochondrial bioenergetics and remodeling mediate aging and the healthspan extending effects of exercise and/or metformin. The lab is also interested in understanding how the mTOR signaling pathway is involved in the initiation and treatment of osteoarthritis.